微粒体是肝、肠、肾、肺等器官经过差速离心制备的亚细胞成分，是细胞器内质网一部分，该部分表达有种类多样的蛋白质。特别是肝微粒体，具有完整的I相代谢酶CYP450酶、FMO酶、MAO酶等，II相代谢酶UGT酶和酯酶等。微粒体在药理药代研究中具有重要价值：体外代谢模型用于预测药物相互作用、代谢表型分型指导个体化用药、酶活性检测评估肝药酶功能状态、新药研发中代谢稳定性测试。
1）高酶活性：CYP、UGT和FMO酶活性验证：
2）完整质控：每批次提供详细COA报告，数据可追溯；
3）批间一致性：凭借标准化的多供体筛选策略与严格的SOP生产体系，有效消除了不同批次间的变异；
4）供体信息透明合规：供体背景透明，来源合规，从根本上保障研究数据的可靠性和可申报性；
5）多物种多组织库：常见实验动物（大鼠、小鼠、犬、猴、猪、兔、猫、仓鼠、豚鼠等）肝、肠、肾、肺组织微粒体体库；
6）长期稳定：-80℃保存，活性保持≧5年。
Metabolic Activity（Male Cynomolgus Liver Microsomes）
Enzyme | Substrate | Conc. (μM) | Metabolite | Metabolic activity (pmol/min/mg) |
CYP1A2 | Phenacetin | 50 | Acetaminophen | 375 |
CYP2B6 | Bupropion | 50 | Bupropion hydroxylation | 387 |
CYP2C/9 | Diclofenac | 10 | 4'-Hydroxydiclofenac | 41 |
CYP3A4 | Testosterone | 50 | Testosterone hydroxylation | 710 |
UGT | 7-Hydroxycoumarin | 30 | 7-Hydroxycoumarin glucuronidation | 1290 |
FMO | TMA | 50 | TMAO | 294 |
已发表部分文献引用列举：
1、Comprehensive Analysis of Pterostilbene Metabolites In Vivo and In Vitro Using a UHPLC-Q-Exactive Plus Mass Spectrometer with Multiple Data-Mining Methods.
期刊：ACS Omega
DOI:10.1021/acsomega.2c03924
影响因子：4.3
2、Comprehensive characterization of narirutin metabolites in vitro and in vivo based on Analogous-Core recursion analysis strategy using UHPLC-Q-Exactive orbitrap MS/MS.
期刊：Arabian Journal of Chemistry
DOI:10.1016/j.arabjc.2023.104949
影响因子：5.3
3、The Analytical Strategy of “Ion Induction and Deduction Based on Net-Hubs” for the Comprehensive Characterization of Naringenin Metabolites In Vivo and In Vitro Using a UHPLC-Q-Exactive orbitrap Mass Spectrometer.
期刊：Molecules
DOI:10.3390/molecules27217282
影响因子：4.6
4、An Extended Strategy of “Recursive Tree” for Characterization of Drug Metabolites in vivo and in vitro and Actional Mechanism Study based on Network Pharmacology: Formononetin as a Study Case.
期刊：Arabian Journal of Chemistry
DOI:10.1016/j.arabjc.2024.105761
影响因子：5.2
5、Serial five-membered lactone ring ions in the treatment of Alzheimer's diseases-comprehensive profiling of arctigenin metabolites and network analysis.
期刊：Front Pharmacol
DOI:10.3389/fphar.2022.1065654
影响因子：4.8
